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Atlas Research Compounds

Research, all in one place.

Compound profiles, the 100-record verified study database, topic clusters, and long-form analysis - merged into a single scrollable view. Use the pills to jump between sections.

97
Compounds
100
Studies
10
Topics
11
Articles

Compound profiles

97 structured profiles organized by research context and evidence maturity. Search by name, alias, category, or evidence level.

Study database

100 PubMed-verified records. Findings are conservative extracts from indexed abstracts, not generated citations.

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AThymosin alpha 1 alleviates inflammation and prevents infection in patients with severe acute pancreatitis through immune regulation: a systematic review and meta-analysisFrontiers in Immunology · 2025 · Meta AnalysisCSemax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.British journal of pharmacology · 2025 · AnimalDSemax, a Copper Chelator Peptide, Decreases the Cu(II)-Catalyzed ROS Production and Cytotoxicity of aβ by Metal Ion Stripping and Redox Silencing.Bioinorganic chemistry and applications · 2025 · ReviewDAging and Thymosin Alpha-1.International journal of molecular sciences · 2025 · ReviewAThe efficacy and safety of thymosin α1 for sepsis (TESTS): multicentre, double-blinded, randomised, placebo-controlled, phase 3 trial.BMJ (Clinical research ed.) · 2025 · Human RctDTopically applied GHK as an anti-wrinkle peptide: advantages, problems, and prospects.BioImpacts : BI · 2025 · ReviewBElamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential.International journal of molecular sciences · 2025 · ReviewCSS-31@Fer-1 Alleviates ferroptosis in hypoxia/reoxygenation cardiomyocytes via mitochondrial targeting.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025 · In VitroCThe glycyl-l-histidyl-l-lysine-Cu(2+) tripeptide complex attenuates lung inflammation and fibrosis in silicosis by targeting peroxiredoxin 6Redox Biology · 2024 · AnimalDGlycyl-l-histidyl-l-lysine prevents copper- and zinc-induced protein aggregation and central nervous system cell death in vitroMetallomics : integrated biometal science · 2024 · In VitroDMitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024 · ReviewDMOTS-c modulates skeletal muscle function by directly binding and activating CK2.iScience · 2024 · ReviewAGenotype-specific effects of elamipretide in patients with primary mitochondrial myopathy: a post hoc analysis of the MMPOWER-3 trial.Orphanet journal of rare diseases · 2024 · Human RctAThe efficacy of thymosin alpha-1 therapy in moderate to critical COVID-19 patients: a systematic review, meta-analysis, and meta-regressionInflammopharmacology · 2023 · Meta AnalysisAA Pilot Trial of Thymalfasin (Thymosin-α-1) to Treat Hospitalized Patients With Hypoxemia and Lymphocytopenia Due to Coronavirus Disease 2019 Infection.The Journal of infectious diseases · 2023 · Human RctBThymosin α-1 in cancer therapy: Immunoregulation and potential applications.International immunopharmacology · 2023 · ReviewDGlycyl-l-histidyl-l-lysine-Cu(2+) rescues cigarette smoking-induced skeletal muscle dysfunction via a sirtuin 1-dependent pathway.Journal of cachexia, sarcopenia and muscle · 2023 · ReviewDLiposomes as Carriers of GHK-Cu Tripeptide for Cosmetic Application.Pharmaceutics · 2023 · ReviewCRelief of ovalbumin-induced airway remodeling by the glycyl-l-histidyl-l-lysine-Cu(2+) tripeptide complex via activation of SIRT1 in airway epithelial cells.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023 · In VitroDMOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.Frontiers in endocrinology · 2023 · ReviewDMOTS-c Functionally Prevents Metabolic Disorders.Metabolites · 2023 · ReviewBMOTS-C: A potential anti-pulmonary fibrosis factor derived from mitochondria.Mitochondrion · 2023 · ReviewDRole of MOTS-c in the regulation of bone metabolism.Frontiers in physiology · 2023 · ReviewCElamipretide(SS-31) Attenuates Idiopathic Pulmonary Fibrosis by Inhibiting the Nrf2-Dependent NLRP3 Inflammasome in Macrophages.Antioxidants (Basel, Switzerland) · 2023 · In VitroAEfficacy and Safety of Elamipretide in Individuals With Primary Mitochondrial Myopathy: The MMPOWER-3 Randomized Clinical Trial.Neurology · 2023 · Human RctDSemax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane ModelsACS Chemical Neuroscience · 2022 · In VitroCBiomimetic Hydrogel Scaffolds with Copper Peptide-Functionalized RADA16 Nanofiber Improve Wound Healing in DiabetesMacromolecular Bioscience · 2022 · AnimalCSelank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.Bulletin of experimental biology and medicine · 2022 · AnimalCThymosin α-1 Reverses M2 Polarization of Tumor-Associated Macrophages during Efferocytosis.Cancer research · 2022 · In VitroDGlycyl-L-histidyl-L-lysine-Cu(2+) attenuates cigarette smoke-induced pulmonary emphysema and inflammation by reducing oxidative-stress pathway activity.Frontiers in molecular biosciences · 2022 · ReviewDThe mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus.Pharmacological research · 2022 · ReviewBMOTS-C, the most recent mitochondrial-derived peptide in human aging and age-related diseases.International journal of molecular sciences · 2022 · Human ObservationalCBrain Protein Expression Profile Confirms the Protective Effect of the ACTH(4-7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-ReperfusionInternational Journal of Molecular Sciences · 2021 · AnimalBEfficacy of Thymosin Alpha 1 in the Treatment of COVID-19: A Multicenter Cohort StudyFrontiers in Immunology · 2021 · Human ObservationalBThymosin Alpha-1 Has no Beneficial Effect on Restoring CD4+ and CD8+ T Lymphocyte Counts in COVID-19 PatientsFrontiers in Immunology · 2021 · Human ObservationalCThymosin Alpha 1 Mitigates Cytokine Storm in Blood Cells From Coronavirus Disease 2019 PatientsOpen Forum Infectious Diseases · 2021 · In VitroCSemax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats.Neuropeptides · 2021 · AnimalDThe Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress.Current reviews in clinical and experimental pharmacology · 2021 · ReviewDElamipretide (SS-31) treatment attenuates age-associated post-translational modifications of heart proteins.GeroScience · 2021 · ReviewCNovel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in RatsGenes · 2020 · AnimalCEDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's DiseaseMolecules (Basel, Switzerland) · 2020 · ReviewAThe clinical efficacy and adverse effects of Entecavir plus Thymosin alpha-1 combination therapy versus Entecavir Monotherapy in HBV-related cirrhosis: a systematic review and meta-analysisBMC Gastroenterology · 2020 · Meta AnalysisCProtective effects of GHK-Cu in bleomycin-induced pulmonary fibrosis via anti-oxidative stress and anti-inflammation pathwaysLife Sciences · 2020 · AnimalDFunctional Connectomic Approach to Studying Selank and Semax Effects.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2020 · ReviewBThe potential of GHK as an anti-aging peptide.Aging pathobiology and therapeutics · 2020 · ReviewDMitochondrial targeted therapy with elamipretide (MTP-131) as an adjunct to tumor necrosis factor inhibition for traumatic optic neuropathy in the acute setting.Experimental eye research · 2020 · ReviewCSelank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in RatsBulletin of Experimental Biology and Medicine · 2019 · AnimalCEffect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress.Bulletin of experimental biology and medicine · 2019 · AnimalDMOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus.BioEssays : news and reviews in molecular, cellular and developmental biology · 2019 · ReviewCElamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.Journal of neuroinflammation · 2019 · AnimalBThe efficacy of Semax in the treatment of patients at different stages of ischemic strokeZhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2018 · Human ObservationalBEffects of Semax on the Default Mode Network of the BrainBulletin of Experimental Biology and Medicine · 2018 · Human ObservationalDPeptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.Protein and peptide letters · 2018 · ReviewBThymosin alpha 1 treatment for patients with sepsis.Expert opinion on biological therapy · 2018 · Human ObservationalBSerum thymosin alpha 1 levels in normal and pathological conditions.Expert opinion on biological therapy · 2018 · Human ObservationalCRegenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data.International journal of molecular sciences · 2018 · AnimalDGABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 CellsFrontiers in Pharmacology · 2017 · In VitroCPeptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in RatsBehavioural Neurology · 2017 · AnimalCSemax, an analog of ACTH((4-7)), regulates expression of immune response genes during ischemic brain injury in rats.Molecular genetics and genomics : MGG · 2017 · AnimalCEffect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons.Bulletin of experimental biology and medicine · 2017 · AnimalCEffect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress.Bulletin of experimental biology and medicine · 2017 · AnimalBThymosin alpha 1 and HIV-1: recent advances and future perspectives.Future microbiology · 2017 · ReviewCThe tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in miceOncotarget · 2016 · AnimalDSemax prevents learning and memory inhibition by heavy metals.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2016 · ReviewCSelank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.Frontiers in pharmacology · 2016 · AnimalCSelank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice.Bulletin of experimental biology and medicine · 2016 · AnimalDImmune Modulation with Thymosin Alpha 1 Treatment.Vitamins and hormones · 2016 · ReviewBOptimization of the treatment of anxiety disorders with selankZhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2015 · Human ObservationalCPinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermiaAdvances in gerontology = Uspekhi gerontologii · 2015 · AnimalCGHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin RegenerationBioMed Research International · 2015 · ReviewB[EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION].Advances in gerontology = Uspekhi gerontologii · 2015 · Human ObservationalDThymosin alpha-1 treatment in chronic hepatitis B.Expert opinion on biological therapy · 2015 · ReviewBHistorical review of thymosin α 1 in infectious diseases.Expert opinion on biological therapy · 2015 · ReviewCTripeptide-copper complex GHK-Cu (II) transiently improved healing outcome in a rat model of ACL reconstruction.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015 · AnimalDThe mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.Cell metabolism · 2015 · ReviewBA comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disordersZhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2014 · Human ObservationalDShort peptides stimulate serotonin expression in cells of brain cortexBulletin of Experimental Biology and Medicine · 2014 · In VitroCThe peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis.BMC genomics · 2014 · AnimalDThe temporal dynamics of inflammation-related gene expression under tuftsin analog Selank action.Molecular immunology · 2014 · ReviewB[Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon].Advances in gerontology = Uspekhi gerontologii · 2014 · Human ObservationalCPinealon protects the rat offspring from prenatal hyperhomocysteinemiaInternational Journal of Clinical and Experimental Medicine · 2012 · AnimalDPinealon increases cell viability by suppression of free radical levels and activating proliferative processesRejuvenation Research · 2011 · In VitroCPenetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.Biochemistry. Biokhimiia · 2011 · AnimalC[Effects of introduction of short peptides before carotid artery occlusion on behaviour and caspase-3 activity in the brain of old rats].Advances in gerontology = Uspekhi gerontologii · 2011 · AnimalD[Cortexin and cortagen as correcting agents in functional and metabolic disorders in the brain in chronic ischemia].Eksperimental'naia i klinicheskaia farmakologiia · 2011 · ReviewDSemax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia.Cellular and molecular neurobiology · 2010 · ReviewD[Investigation of antihypoxic properties of short peptides].Advances in gerontology = Uspekhi gerontologii · 2008 · ReviewDSelank and its metabolites maintain homeostasis in the gastric mucosa.Bulletin of experimental biology and medicine · 2007 · ReviewDEffects of bioactive tetrapeptides on free-radical processes.Bulletin of experimental biology and medicine · 2007 · ReviewCSemax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain.Journal of neurochemistry · 2006 · AnimalDSemax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents.Neurochemical research · 2005 · ReviewCElucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray.Neuro endocrinology letters · 2004 · AnimalBThymalfasin (thymosin-alpha 1) therapy in patients with chronic hepatitis B.Journal of gastroenterology and hepatology · 2004 · Human ObservationalCThe delayed effect of cortagen on the restoration of injured nerve function.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2002 · AnimalDThymosin alpha-1.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2001 · ReviewCEffect of tetrapeptide cortagen on regeneration of sciatic nerve.Bulletin of experimental biology and medicine · 2000 · AnimalCThe tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures.Life sciences · 2000 · In VitroBClinical applications of thymosin alpha-1.Cancer investigation · 1994 · ReviewCIn vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental woundsThe Journal of Clinical Investigation · 1993 · AnimalCStimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+.FEBS letters · 1988 · In Vitro

Research articles

Methods, evidence frameworks, and field guides for reading emerging research with restraint.

Research methods · Lead analysis

How to read peptide research without outrunning the evidence

A practical framework for separating mechanism, model, and measured outcome.

7 min read · Read analysis

Metabolic signaling

Mitochondrial-derived peptides: a field guide

Where encoded micropeptides fit within mitochondrial communication research.

6 min read

Editorial standards

Evidence labels in the Atlas catalog

What our evidence labels mean, and what they deliberately do not mean.

4 min read

Neuroprotection

What Is Semax?

A research-first explanation of Semax, its ACTH-fragment origin, verified study coverage, and where the evidence remains bounded.

10 min read

Cognition

What Is Selank?

A citation-backed overview of Selank as a tuftsin-related neuropeptide with stress-response, neurochemical, and immune-neural literature.

9 min read

Healthy aging

Pinealon Review

A bounded review of Pinealon, EDR-related publications, short-peptide bioregulator context, and the limits of the verified record.

9 min read

Neuroprotection

Cortagen Review

A structured Cortagen review covering tetrapeptide identity, neural bioregulator context, verified PubMed records, and citation limits.

8 min read

Immune function

TA1 Research Overview

A PubMed-backed overview of thymosin alpha 1 across immune modulation, infection, sepsis, oncology, and evidence maturity.

10 min read

Peptide research

GHK-Cu Research Overview

A research overview of GHK-Cu, matrix biology, copper coordination, skin models, lung injury models, and regeneration claims.

10 min read

Mitochondrial health

MOTS-C Research Overview

A mitochondrial-derived peptide overview covering MOTS-C metabolism, stress signaling, aging literature, and verified study mapping.

10 min read

Mitochondrial health

SS-31 Research Overview

A structured SS-31 and elamipretide overview covering mitochondrial targeting, cardiolipin context, animal models, and clinical trial records.

10 min read