Verified publication
Thymosin alpha 1 alleviates inflammation and prevents infection in patients with severe acute pancreatitis through immune regulation: a systematic review and meta-analysis
A systematic review and meta-analysis of five randomized studies in severe acute pancreatitis.
Indexed abstract extractedQuality: HighHigh confidence
Study metadata
- Journal
- Frontiers in Immunology
- Publication year
- 2025
- Study type
- Systematic review and meta-analysis
- Species
- Human
- Evidence grade
- Grade A
- Extraction depth
- Indexed abstract extracted
- Study quality
- High
- Confidence
- High confidence
- Sample size
- 706
Structured extraction
- Population
- Human participants; population details require article-level extraction.
- Intervention
- Evidence synthesis; intervention definitions vary by included study.
- Comparator
- Not stated or not fully extracted from the indexed abstract.
- Duration
- Not stated or not fully extracted from the indexed abstract.
- Primary endpoint
- Pooled endpoint definitions require full review of the article and included studies.
- Secondary endpoints
- No secondary endpoints extracted.
- Funding source
- Not stated in the indexed abstract.
Findings and extraction notes
- The pooled analysis reports higher CD4 measures and lower extrapancreatic infection incidence, while hospital stay was not significantly reduced.
Limitations
- Only five trials were included and dose-stratified inflammatory results were inconsistent.
- The authors state that additional research is needed to validate the findings.