Verified publication
The clinical efficacy and adverse effects of Entecavir plus Thymosin alpha-1 combination therapy versus Entecavir Monotherapy in HBV-related cirrhosis: a systematic review and meta-analysis
A systematic review and meta-analysis of seven randomized studies comparing entecavir plus thymosin alpha-1 with entecavir alone.
Indexed abstract extractedQuality: HighHigh confidence
Study metadata
- Journal
- BMC Gastroenterology
- Publication year
- 2020
- Study type
- Systematic review and meta-analysis
- Species
- Human
- Evidence grade
- Grade A
- Extraction depth
- Indexed abstract extracted
- Study quality
- High
- Confidence
- High confidence
- Sample size
- 1144
Structured extraction
- Population
- Human participants; population details require article-level extraction.
- Intervention
- Evidence synthesis; intervention definitions vary by included study.
- Comparator
- Not stated or not fully extracted from the indexed abstract.
- Duration
- Not stated or not fully extracted from the indexed abstract.
- Primary endpoint
- Pooled endpoint definitions require full review of the article and included studies.
- Secondary endpoints
- No secondary endpoints extracted.
- Funding source
- Not stated in the indexed abstract.
Findings and extraction notes
- The pooled analysis reports some earlier virologic and clinical-response differences, with several effects no longer significant at later time points.
Limitations
- All included participants were from mainland China and several outcomes showed substantial heterogeneity.
- The intervention was combination therapy, so results do not isolate thymosin alpha-1.