Verified publication
The efficacy of thymosin alpha-1 therapy in moderate to critical COVID-19 patients: a systematic review, meta-analysis, and meta-regression
A synthesis of eight studies evaluating thymosin alpha-1 in moderate-to-critical COVID-19.
Indexed abstract extractedQuality: HighHigh confidence
Study metadata
- Journal
- Inflammopharmacology
- Publication year
- 2023
- Study type
- Systematic review and meta-analysis
- Species
- Human
- Evidence grade
- Grade A
- Extraction depth
- Indexed abstract extracted
- Study quality
- High
- Confidence
- High confidence
- Sample size
- Not stated in indexed abstract
Structured extraction
- Population
- Human participants; population details require article-level extraction.
- Intervention
- Evidence synthesis; intervention definitions vary by included study.
- Comparator
- Not stated or not fully extracted from the indexed abstract.
- Duration
- Not stated or not fully extracted from the indexed abstract.
- Primary endpoint
- Pooled endpoint definitions require full review of the article and included studies.
- Secondary endpoints
- No secondary endpoints extracted.
- Funding source
- Not stated in the indexed abstract.
Findings and extraction notes
- Pooled mortality was lower, while mechanical-ventilation use and hospital stay were not significantly different in the reported analysis.
Limitations
- Heterogeneity was high across mortality, ventilation, and length-of-stay analyses.
- The authors state that randomized trials are still required.