Verified publication
Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats
An RNA-sequencing analysis of Semax in a rat transient middle cerebral artery occlusion model.
Indexed abstract extractedQuality: LowLow confidence
Study metadata
- Journal
- Genes
- Publication year
- 2020
- Study type
- Animal study
- Species
- Rat
- Evidence grade
- Grade C
- Extraction depth
- Indexed abstract extracted
- Study quality
- Low
- Confidence
- Low confidence
- Sample size
- Not stated in indexed abstract
Structured extraction
- Population
- Rat model; strain and model details require article-level extraction.
- Intervention
- Animal-model exposure details require abstract or full-text extraction before use.
- Comparator
- Not stated or not fully extracted from the indexed abstract.
- Duration
- Not stated or not fully extracted from the indexed abstract.
- Primary endpoint
- Primary animal-model endpoint not fully extracted.
- Secondary endpoints
- No secondary endpoints extracted.
- Funding source
- Not stated in the indexed abstract.
Findings and extraction notes
- The abstract reports 394 differentially expressed genes, with inflammatory transcripts suppressed and neurotransmission-related transcripts activated relative to saline.
Limitations
- Transcriptomic associations do not by themselves establish a direct molecular target.
- The model and reported endpoints are preclinical.