Verified publication
Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4-7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion
A rat transient middle cerebral artery occlusion study examining proteins associated with inflammation, cell death, neuroprotection, and recovery.
Indexed abstract extractedQuality: LowLow confidence
Study metadata
- Journal
- International Journal of Molecular Sciences
- Publication year
- 2021
- Study type
- Animal study
- Species
- Rat
- Evidence grade
- Grade C
- Extraction depth
- Indexed abstract extracted
- Study quality
- Low
- Confidence
- Low confidence
- Sample size
- Not stated in indexed abstract
Structured extraction
- Population
- Rat model; strain and model details require article-level extraction.
- Intervention
- Animal-model exposure details require abstract or full-text extraction before use.
- Comparator
- Not stated or not fully extracted from the indexed abstract.
- Duration
- Not stated or not fully extracted from the indexed abstract.
- Primary endpoint
- Primary animal-model endpoint not fully extracted.
- Secondary endpoints
- No secondary endpoints extracted.
- Funding source
- Not stated in the indexed abstract.
Findings and extraction notes
- The abstract reports increased active CREB and reduced MMP-9, c-Fos, and active JNK after Semax in sampled brain regions.
Limitations
- This is a rat ischemia-reperfusion model and does not establish human clinical effects.
- The abstract does not provide the animal count.