Neuropeptides
Semax
A synthetic heptapeptide derived from an ACTH fragment.
Evidence score2/5
Early human evidence
- Evidence
- Early clinical
- Status
- Published
Topic authority hub
Neuroprotection
Stroke, nerve-injury, stress, mitochondrial, and cellular models organized without turning preclinical signals into human claims.
Research frame
Neuroprotection is an evidence-sensitive topic because animal injury models, cell survival assays, and human neurological outcomes do not answer the same question.
This hub brings together Semax, Selank, Pinealon, Cortagen, and SS-31 pages while keeping study type and species visible.
Featured compounds
Neuropeptides
Selank
A synthetic tuftsin-related heptapeptide.
Evidence score2/5
Early human evidence
- Evidence
- Early clinical
- Status
- Published
Bioregulatory peptides
Pinealon
A short synthetic tripeptide studied in bioregulation models.
Evidence score1/5
Preclinical foundation
- Evidence
- Preclinical
- Status
- Published
Bioregulatory peptides
Cortagen
A tetrapeptide investigated within short-peptide bioregulation research.
Evidence score1/5
Preclinical foundation
- Evidence
- Preclinical
- Status
- Published
Metabolic signaling
SS-31
A mitochondria-targeted tetrapeptide indexed in the literature as elamipretide and MTP-131.
Evidence score3/5
Developing clinical evidence
- Evidence
- Mixed translational
- Status
- Published
Featured studies
Grade BHuman observational study2018Indexed abstract extracted
The efficacy of Semax in the treatment of patients at different stages of ischemic stroke
A rehabilitation-stage comparison that followed 110 people after ischemic stroke and assessed plasma BDNF, motor performance, and Barthel index scores.
- Journal
- Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
- Evidence context
- Human comparative or observational evidence
Grade CAnimal study2000PubMed metadata verified
Effect of tetrapeptide cortagen on regeneration of sciatic nerve.
Verified PubMed record for Cortagen: Effect of tetrapeptide cortagen on regeneration of sciatic nerve.
- Journal
- Bulletin of experimental biology and medicine
- Evidence context
- Preclinical or narrative synthesis
Grade CAnimal study2019PubMed metadata verified
Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.
Verified PubMed record for SS-31: Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.
- Journal
- Journal of neuroinflammation
- Evidence context
- Preclinical or narrative synthesis
Comparisons
Semax vs. SelankTwo synthetic neuropeptides with different source motifs and overlapping but non-equivalent cognition and stress-response research contexts.Semax vs. NoopeptA structured research comparison between Semax and Noopept across compound identity, research category, evidence maturity, and interpretation boundaries.Pinealon vs. SemaxA structured research comparison between Pinealon and Semax across compound identity, research category, evidence maturity, and interpretation boundaries.MOTS-C vs. SS-31A structured research comparison between MOTS-C and SS-31 across compound identity, research category, evidence maturity, and interpretation boundaries.
Authority articles
Neuroprotection
What Is Semax?
Semax has a wider publication footprint than many catalog neuropeptides, but the literature still separates mechanistic models from human inference.
Cognition
What Is Selank?
Selank’s strongest catalog value is as a mapped research cluster, not as a single simplified mechanism claim.
Neuroprotection
Cortagen Review
Cortagen’s research map is narrower than its marketing language often suggests, so the page starts with verified records and stops at their boundary.
Mitochondrial health
SS-31 Research Overview
SS-31 has enough translational literature to deserve its own hub role, but the evidence is still endpoint- and disease-context dependent.