Verified publication
In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds
A rat wound-chamber experiment measuring matrix composition and collagen-related messenger RNA after local GHK-Cu exposure.
Indexed abstract extractedQuality: LowLow confidence
Study metadata
- Journal
- The Journal of Clinical Investigation
- Publication year
- 1993
- Study type
- Animal study
- Species
- Rat
- Evidence grade
- Grade C
- Extraction depth
- Indexed abstract extracted
- Study quality
- Low
- Confidence
- Low confidence
- Sample size
- Not stated in indexed abstract
Structured extraction
- Population
- Rat model; strain and model details require article-level extraction.
- Intervention
- Animal-model exposure details require abstract or full-text extraction before use.
- Comparator
- Not stated or not fully extracted from the indexed abstract.
- Duration
- Not stated or not fully extracted from the indexed abstract.
- Primary endpoint
- Primary animal-model endpoint not fully extracted.
- Secondary endpoints
- No secondary endpoints extracted.
- Funding source
- Not stated in the indexed abstract.
Findings and extraction notes
- The abstract reports concentration-dependent increases in wound-chamber dry weight, DNA, protein, collagen, and glycosaminoglycans.
Limitations
- A wound-chamber model is not equivalent to ordinary wound healing or human clinical use.
- The abstract does not state the number of animals.