Verified publication
The glycyl-l-histidyl-l-lysine-Cu(2+) tripeptide complex attenuates lung inflammation and fibrosis in silicosis by targeting peroxiredoxin 6
A mouse silicosis model with complementary RAW264.7 macrophage experiments and target investigation involving peroxiredoxin 6.
Indexed abstract extractedQuality: LowLow confidence
Study metadata
- Journal
- Redox Biology
- Publication year
- 2024
- Study type
- Animal study
- Species
- Mouse
- Evidence grade
- Grade C
- Extraction depth
- Indexed abstract extracted
- Study quality
- Low
- Confidence
- Low confidence
- Sample size
- Not stated in indexed abstract
Structured extraction
- Population
- Mouse model; strain and model details require article-level extraction.
- Intervention
- Animal-model exposure details require abstract or full-text extraction before use.
- Comparator
- Not stated or not fully extracted from the indexed abstract.
- Duration
- Not stated or not fully extracted from the indexed abstract.
- Primary endpoint
- Primary animal-model endpoint not fully extracted.
- Secondary endpoints
- No secondary endpoints extracted.
- Funding source
- Not stated in the indexed abstract.
Findings and extraction notes
- The abstract reports less lung inflammation and fibrosis and identifies PRDX6 binding as part of the proposed oxidative-stress mechanism.
Limitations
- The evidence is preclinical and combines animal and cell-model findings.
- The abstract does not provide the number of animals.