Verified publication
GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells
A qPCR study of 84 GABAergic and neurotransmission-related genes in IMR-32 neuroblastoma cells.
Indexed abstract extractedQuality: LowLow confidence
Study metadata
- Journal
- Frontiers in Pharmacology
- Publication year
- 2017
- Study type
- In vitro study
- Species
- Cell or artificial model
- Evidence grade
- Grade D
- Extraction depth
- Indexed abstract extracted
- Study quality
- Low
- Confidence
- Low confidence
- Sample size
- Not stated in indexed abstract
Structured extraction
- Population
- Cell or artificial model; cell line and assay details require article-level extraction.
- Intervention
- In vitro exposure details require abstract or full-text extraction before use.
- Comparator
- Not stated or not fully extracted from the indexed abstract.
- Duration
- Not stated or not fully extracted from the indexed abstract.
- Primary endpoint
- Primary assay endpoint not fully extracted.
- Secondary endpoints
- No secondary endpoints extracted.
- Funding source
- Not stated in the indexed abstract.
Findings and extraction notes
- Selank alone did not change the measured mRNA levels, while combined exposures modified GABA- and olanzapine-associated expression patterns.
Limitations
- A neuroblastoma cell line cannot reproduce whole-brain pharmacology or clinical effects.
- Gene-expression changes do not establish receptor binding or functional outcomes.