Verified publication
Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes
An in vitro study across cerebellar granule cells, neutrophils, and PC12 cells under induced oxidative stress.
Indexed abstract extractedQuality: LowLow confidence
Study metadata
- Journal
- Rejuvenation Research
- Publication year
- 2011
- Study type
- In vitro study
- Species
- Cell or artificial model
- Evidence grade
- Grade D
- Extraction depth
- Indexed abstract extracted
- Study quality
- Low
- Confidence
- Low confidence
- Sample size
- Not stated in indexed abstract
Structured extraction
- Population
- Cell or artificial model; cell line and assay details require article-level extraction.
- Intervention
- In vitro exposure details require abstract or full-text extraction before use.
- Comparator
- Not stated or not fully extracted from the indexed abstract.
- Duration
- Not stated or not fully extracted from the indexed abstract.
- Primary endpoint
- Primary assay endpoint not fully extracted.
- Secondary endpoints
- No secondary endpoints extracted.
- Funding source
- Not stated in the indexed abstract.
Findings and extraction notes
- The abstract reports dose-dependent restriction of reactive oxygen species, lower necrotic-cell measures, delayed ERK1/2 activation, and cell-cycle changes.
Limitations
- The tested cell systems do not establish organism-level efficacy or safety.
- The proposed direct genome interaction is an interpretation rather than demonstrated binding in the abstract.