Verified publication
Short peptides stimulate serotonin expression in cells of brain cortex
A cell-culture and molecular-docking study of Glu-Asp-Arg and Lys-Glu-Asp in aging brain-cortex cell cultures.
Indexed abstract extractedQuality: LowLow confidence
Study metadata
- Journal
- Bulletin of Experimental Biology and Medicine
- Publication year
- 2014
- Study type
- In vitro study
- Species
- Cell or artificial model
- Evidence grade
- Grade D
- Extraction depth
- Indexed abstract extracted
- Study quality
- Low
- Confidence
- Low confidence
- Sample size
- Not stated in indexed abstract
Structured extraction
- Population
- Cell or artificial model; cell line and assay details require article-level extraction.
- Intervention
- In vitro exposure details require abstract or full-text extraction before use.
- Comparator
- Not stated or not fully extracted from the indexed abstract.
- Duration
- Not stated or not fully extracted from the indexed abstract.
- Primary endpoint
- Primary assay endpoint not fully extracted.
- Secondary endpoints
- No secondary endpoints extracted.
- Funding source
- Not stated in the indexed abstract.
Findings and extraction notes
- The abstract reports increased serotonin expression in culture and a proposed complementary interaction with a tryptophan-hydroxylase gene sequence.
Limitations
- Molecular docking and cultured-cell expression do not establish direct genomic regulation in vivo.
- The abstract does not identify independent replication.