Grade CAnimal study·2021Indexed abstract extracted
Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4-7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion
A rat transient middle cerebral artery occlusion study examining proteins associated with inflammation, cell death, neuroprotection, and recovery.
- Journal
- International Journal of Molecular Sciences
- Evidence context
- Preclinical or narrative synthesis
Review study record →Grade CAnimal study·2020Indexed abstract extracted
Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats
An RNA-sequencing analysis of Semax in a rat transient middle cerebral artery occlusion model.
- Journal
- Genes
- Evidence context
- Preclinical or narrative synthesis
Review study record →Grade DIn vitro study·2022Indexed abstract extracted
Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models
A spectrofluorometric, calorimetric, and cell-viability investigation of Semax in copper-associated amyloid-beta aggregation models.
- Journal
- ACS Chemical Neuroscience
- Evidence context
- Metadata-only, mechanistic, or limited evidence
Review study record →Grade CAnimal study·2025PubMed metadata verified
Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.
Verified PubMed record for Semax: Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.
- Journal
- British journal of pharmacology
- Evidence context
- Preclinical or narrative synthesis
Review study record →Grade CAnimal study·2021PubMed metadata verified
Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats.
Verified PubMed record for Semax: Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats.
- Journal
- Neuropeptides
- Evidence context
- Preclinical or narrative synthesis
Review study record →Grade DReview·2005PubMed metadata verified
Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents.
Verified PubMed record for Semax: Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents.
- Journal
- Neurochemical research
- Evidence context
- Metadata-only, mechanistic, or limited evidence
Review study record →Grade DReview·2010PubMed metadata verified
Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia.
Verified PubMed record for Semax: Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia.
- Journal
- Cellular and molecular neurobiology
- Evidence context
- Metadata-only, mechanistic, or limited evidence
Review study record →Grade DReview·2025PubMed metadata verified
Semax, a Copper Chelator Peptide, Decreases the Cu(II)-Catalyzed ROS Production and Cytotoxicity of aβ by Metal Ion Stripping and Redox Silencing.
Verified PubMed record for Semax: Semax, a Copper Chelator Peptide, Decreases the Cu(II)-Catalyzed ROS Production and Cytotoxicity of aβ by Metal Ion Stripping and Redox Silencing.
- Journal
- Bioinorganic chemistry and applications
- Evidence context
- Metadata-only, mechanistic, or limited evidence
Review study record →Grade CAnimal study·2006PubMed metadata verified
Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain.
Verified PubMed record for Semax: Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain.
- Journal
- Journal of neurochemistry
- Evidence context
- Preclinical or narrative synthesis
Review study record →Grade CAnimal study·2017PubMed metadata verified
Semax, an analog of ACTH((4-7)), regulates expression of immune response genes during ischemic brain injury in rats.
Verified PubMed record for Semax: Semax, an analog of ACTH((4-7)), regulates expression of immune response genes during ischemic brain injury in rats.
- Journal
- Molecular genetics and genomics : MGG
- Evidence context
- Preclinical or narrative synthesis
Review study record →Grade DReview·2016PubMed metadata verified
Semax prevents learning and memory inhibition by heavy metals.
Verified PubMed record for Semax: Semax prevents learning and memory inhibition by heavy metals.
- Journal
- Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections
- Evidence context
- Metadata-only, mechanistic, or limited evidence
Review study record →Grade DReview·2020PubMed metadata verified
Functional Connectomic Approach to Studying Selank and Semax Effects.
Verified PubMed record for Semax: Functional Connectomic Approach to Studying Selank and Semax Effects.
- Journal
- Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections
- Evidence context
- Metadata-only, mechanistic, or limited evidence
Review study record →Grade CAnimal study·2014PubMed metadata verified
The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis.
Verified PubMed record for Semax: The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis.
- Journal
- BMC genomics
- Evidence context
- Preclinical or narrative synthesis
Review study record →