What kind of evidence is included on the Semax animal studies page?

Only PubMed-verified publications and explicitly labeled editorial-review gaps are included.

Does this page provide medical advice or human-use guidance?

No. Atlas provides an educational publication map and does not provide sourcing, human-use instructions, or individual medical guidance.

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Semax: Animal studies

Preclinical animal models and the boundaries on translating their results.

Publication records

7 verified studies

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Grade CAnimal study2021Indexed abstract extracted

Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4-7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion

A rat transient middle cerebral artery occlusion study examining proteins associated with inflammation, cell death, neuroprotection, and recovery.

Journal: International Journal of Molecular Sciences
Evidence context: Preclinical or narrative synthesis

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Grade CAnimal study2020Indexed abstract extracted

Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats

An RNA-sequencing analysis of Semax in a rat transient middle cerebral artery occlusion model.

Journal: Genes
Evidence context: Preclinical or narrative synthesis

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Grade CAnimal study2025PubMed metadata verified

Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.

Verified PubMed record for Semax: Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.

Journal: British journal of pharmacology
Evidence context: Preclinical or narrative synthesis

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Grade CAnimal study2021PubMed metadata verified

Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats.

Verified PubMed record for Semax: Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats.

Journal: Neuropeptides
Evidence context: Preclinical or narrative synthesis

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Grade CAnimal study2006PubMed metadata verified

Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain.

Verified PubMed record for Semax: Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain.

Journal: Journal of neurochemistry
Evidence context: Preclinical or narrative synthesis

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Grade CAnimal study2017PubMed metadata verified

Semax, an analog of ACTH((4-7)), regulates expression of immune response genes during ischemic brain injury in rats.

Verified PubMed record for Semax: Semax, an analog of ACTH((4-7)), regulates expression of immune response genes during ischemic brain injury in rats.

Journal: Molecular genetics and genomics : MGG
Evidence context: Preclinical or narrative synthesis

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Grade CAnimal study2014PubMed metadata verified

The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis.

Verified PubMed record for Semax: The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis.

Journal: BMC genomics
Evidence context: Preclinical or narrative synthesis

Review study record →

Model inventory

Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4-7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion: Rat
Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats: Rat
Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.: Mouse
Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats.: Rat
Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain.: Rat
Semax, an analog of ACTH((4-7)), regulates expression of immune response genes during ischemic brain injury in rats.: Rat
The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis.: Rat

Semax: Animal studies

7 verified studies

Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4-7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion

Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats

Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.

Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats.

Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain.

Semax, an analog of ACTH((4-7)), regulates expression of immune response genes during ischemic brain injury in rats.

The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis.

Model inventory

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