GHK-Cu: Research history

Verified publication timeline

1. 1988Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+.Study →
2. 1993In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental woundsStudy →
3. 2000The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures.Study →
4. 2015GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin RegenerationStudy →
5. 2015Tripeptide-copper complex GHK-Cu (II) transiently improved healing outcome in a rat model of ACL reconstruction.Study →
6. 2016The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in miceStudy →
7. 2018Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data.Study →
8. 2020Protective effects of GHK-Cu in bleomycin-induced pulmonary fibrosis via anti-oxidative stress and anti-inflammation pathwaysStudy →
9. 2020The potential of GHK as an anti-aging peptide.Study →
10. 2022Biomimetic Hydrogel Scaffolds with Copper Peptide-Functionalized RADA16 Nanofiber Improve Wound Healing in DiabetesStudy →
11. 2022Glycyl-L-histidyl-L-lysine-Cu(2+) attenuates cigarette smoke-induced pulmonary emphysema and inflammation by reducing oxidative-stress pathway activity.Study →
12. 2023Glycyl-l-histidyl-l-lysine-Cu(2+) rescues cigarette smoking-induced skeletal muscle dysfunction via a sirtuin 1-dependent pathway.Study →
13. 2023Liposomes as Carriers of GHK-Cu Tripeptide for Cosmetic Application.Study →
14. 2023Relief of ovalbumin-induced airway remodeling by the glycyl-l-histidyl-l-lysine-Cu(2+) tripeptide complex via activation of SIRT1 in airway epithelial cells.Study →
15. 2024The glycyl-l-histidyl-l-lysine-Cu(2+) tripeptide complex attenuates lung inflammation and fibrosis in silicosis by targeting peroxiredoxin 6Study →
16. 2024Glycyl-l-histidyl-l-lysine prevents copper- and zinc-induced protein aggregation and central nervous system cell death in vitroStudy →
17. 2025Topically applied GHK as an anti-wrinkle peptide: advantages, problems, and prospects.Study →