Grade CReview·2020Indexed abstract extracted
EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease
A narrative review of proposed EDR peptide effects on gene expression, protein synthesis, apoptosis, antioxidant systems, and neuronal models.
- Journal
- Molecules (Basel, Switzerland)
- Evidence context
- Preclinical or narrative synthesis
Review study record →Grade CAnimal study·2015Indexed abstract extracted
Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia
A study of Pinealon and Cortexin in 18-month-old rats exposed to acute hypobaric hypoxia or mild hypothermia.
- Journal
- Advances in gerontology = Uspekhi gerontologii
- Evidence context
- Preclinical or narrative synthesis
Review study record →Grade DIn vitro study·2014Indexed abstract extracted
Short peptides stimulate serotonin expression in cells of brain cortex
A cell-culture and molecular-docking study of Glu-Asp-Arg and Lys-Glu-Asp in aging brain-cortex cell cultures.
- Journal
- Bulletin of Experimental Biology and Medicine
- Evidence context
- Metadata-only, mechanistic, or limited evidence
Review study record →Grade CAnimal study·2012Indexed abstract extracted
Pinealon protects the rat offspring from prenatal hyperhomocysteinemia
A prenatal methionine-loading rat model examining offspring learning, spatial orientation, oxidative stress, and cerebellar-neuron viability.
- Journal
- International Journal of Clinical and Experimental Medicine
- Evidence context
- Preclinical or narrative synthesis
Review study record →Grade DIn vitro study·2011Indexed abstract extracted
Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes
An in vitro study across cerebellar granule cells, neutrophils, and PC12 cells under induced oxidative stress.
- Journal
- Rejuvenation Research
- Evidence context
- Metadata-only, mechanistic, or limited evidence
Review study record →Grade BHuman observational study·2014PubMed metadata verified
[Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon].
Verified PubMed record for Pinealon: [Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon].
- Journal
- Advances in gerontology = Uspekhi gerontologii
- Evidence context
- Human comparative or observational evidence
Review study record →Grade BHuman observational study·2015PubMed metadata verified
[EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION].
Verified PubMed record for Pinealon: [EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION].
- Journal
- Advances in gerontology = Uspekhi gerontologii
- Evidence context
- Human comparative or observational evidence
Review study record →Grade CAnimal study·2011PubMed metadata verified
Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.
Verified PubMed record for Pinealon: Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.
- Journal
- Biochemistry. Biokhimiia
- Evidence context
- Preclinical or narrative synthesis
Review study record →Grade DReview·2008PubMed metadata verified
[Investigation of antihypoxic properties of short peptides].
Verified PubMed record for Pinealon: [Investigation of antihypoxic properties of short peptides].
- Journal
- Advances in gerontology = Uspekhi gerontologii
- Evidence context
- Metadata-only, mechanistic, or limited evidence
Review study record →Grade CAnimal study·2011PubMed metadata verified
[Effects of introduction of short peptides before carotid artery occlusion on behaviour and caspase-3 activity in the brain of old rats].
Verified PubMed record for Pinealon: [Effects of introduction of short peptides before carotid artery occlusion on behaviour and caspase-3 activity in the brain of old rats].
- Journal
- Advances in gerontology = Uspekhi gerontologii
- Evidence context
- Preclinical or narrative synthesis
Review study record →