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Atlas Research Compounds

Selank: Mechanism

Mechanistic pathways reported in verified publications, separated from clinical inference.

Mechanistic frame

Investigated in neurochemical, stress-response, and immune-neural signaling models. Mechanistic records below are organized by their actual experimental system. They do not prove a clinical effect.

14 verified studies

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Grade CAnimal study2019Indexed abstract extracted

Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats

A rat study of object recognition and brain-derived neurotrophic factor after chronic ethanol exposure and withdrawal.

Journal
Bulletin of Experimental Biology and Medicine
Evidence context
Preclinical or narrative synthesis
Review study record →
Grade DIn vitro study2017Indexed abstract extracted

GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells

A qPCR study of 84 GABAergic and neurotransmission-related genes in IMR-32 neuroblastoma cells.

Journal
Frontiers in Pharmacology
Evidence context
Metadata-only, mechanistic, or limited evidence
Review study record →
Grade CAnimal study2017Indexed abstract extracted

Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats

An elevated-plus-maze study of individual and combined Selank and diazepam exposure in rats with and without chronic mild stress.

Journal
Behavioural Neurology
Evidence context
Preclinical or narrative synthesis
Review study record →
Grade DReview2020PubMed metadata verified

Functional Connectomic Approach to Studying Selank and Semax Effects.

Verified PubMed record for Semax: Functional Connectomic Approach to Studying Selank and Semax Effects.

Journal
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections
Evidence context
Metadata-only, mechanistic, or limited evidence
Review study record →
Grade CAnimal study2022PubMed metadata verified

Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.

Verified PubMed record for Selank: Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.

Journal
Bulletin of experimental biology and medicine
Evidence context
Preclinical or narrative synthesis
Review study record →
Grade DReview2021PubMed metadata verified

The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress.

Verified PubMed record for Selank: The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress.

Journal
Current reviews in clinical and experimental pharmacology
Evidence context
Metadata-only, mechanistic, or limited evidence
Review study record →
Grade CAnimal study2019PubMed metadata verified

Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress.

Verified PubMed record for Selank: Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress.

Journal
Bulletin of experimental biology and medicine
Evidence context
Preclinical or narrative synthesis
Review study record →
Grade CAnimal study2016PubMed metadata verified

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.

Verified PubMed record for Selank: Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.

Journal
Frontiers in pharmacology
Evidence context
Preclinical or narrative synthesis
Review study record →
Grade CAnimal study2016PubMed metadata verified

Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice.

Verified PubMed record for Selank: Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice.

Journal
Bulletin of experimental biology and medicine
Evidence context
Preclinical or narrative synthesis
Review study record →
Grade DReview2018PubMed metadata verified

Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.

Verified PubMed record for Selank: Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.

Journal
Protein and peptide letters
Evidence context
Metadata-only, mechanistic, or limited evidence
Review study record →
Grade CAnimal study2017PubMed metadata verified

Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons.

Verified PubMed record for Selank: Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons.

Journal
Bulletin of experimental biology and medicine
Evidence context
Preclinical or narrative synthesis
Review study record →
Grade DReview2014PubMed metadata verified

The temporal dynamics of inflammation-related gene expression under tuftsin analog Selank action.

Verified PubMed record for Selank: The temporal dynamics of inflammation-related gene expression under tuftsin analog Selank action.

Journal
Molecular immunology
Evidence context
Metadata-only, mechanistic, or limited evidence
Review study record →
Grade DReview2007PubMed metadata verified

Selank and its metabolites maintain homeostasis in the gastric mucosa.

Verified PubMed record for Selank: Selank and its metabolites maintain homeostasis in the gastric mucosa.

Journal
Bulletin of experimental biology and medicine
Evidence context
Metadata-only, mechanistic, or limited evidence
Review study record →
Grade CAnimal study2017PubMed metadata verified

Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress.

Verified PubMed record for Selank: Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress.

Journal
Bulletin of experimental biology and medicine
Evidence context
Preclinical or narrative synthesis
Review study record →

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