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Atlas Research Compounds

MOTS-C: Safety evidence

What the verified publication set can and cannot establish about safety.

Safety evidence boundary

Atlas does not infer safety from absence of an adverse-event statement. The records below are included only when the verified publication set provides relevant human context or identifies material design limitations.

10 verified studies

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Grade DReview2023PubMed metadata verified

MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.

Verified PubMed record for MOTS-C: MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.

Journal
Frontiers in endocrinology
Evidence context
Metadata-only, mechanistic, or limited evidence
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Grade DReview2023PubMed metadata verified

MOTS-c Functionally Prevents Metabolic Disorders.

Verified PubMed record for MOTS-C: MOTS-c Functionally Prevents Metabolic Disorders.

Journal
Metabolites
Evidence context
Metadata-only, mechanistic, or limited evidence
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Grade DReview2019PubMed metadata verified

MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus.

Verified PubMed record for MOTS-C: MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus.

Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
Evidence context
Metadata-only, mechanistic, or limited evidence
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Grade DReview2015PubMed metadata verified

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.

Verified PubMed record for MOTS-C: The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.

Journal
Cell metabolism
Evidence context
Metadata-only, mechanistic, or limited evidence
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Grade DReview2024PubMed metadata verified

Mitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination.

Verified PubMed record for MOTS-C: Mitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination.

Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Evidence context
Metadata-only, mechanistic, or limited evidence
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Grade BReview2023PubMed metadata verified

MOTS-C: A potential anti-pulmonary fibrosis factor derived from mitochondria.

Verified PubMed record for MOTS-C: MOTS-C: A potential anti-pulmonary fibrosis factor derived from mitochondria.

Journal
Mitochondrion
Evidence context
Human comparative or observational evidence
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Grade DReview2022PubMed metadata verified

The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus.

Verified PubMed record for MOTS-C: The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus.

Journal
Pharmacological research
Evidence context
Metadata-only, mechanistic, or limited evidence
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Grade DReview2023PubMed metadata verified

Role of MOTS-c in the regulation of bone metabolism.

Verified PubMed record for MOTS-C: Role of MOTS-c in the regulation of bone metabolism.

Journal
Frontiers in physiology
Evidence context
Metadata-only, mechanistic, or limited evidence
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Grade BHuman observational study2022PubMed metadata verified

MOTS-C, the most recent mitochondrial-derived peptide in human aging and age-related diseases.

Verified PubMed record for MOTS-C: MOTS-C, the most recent mitochondrial-derived peptide in human aging and age-related diseases.

Journal
International journal of molecular sciences
Evidence context
Human comparative or observational evidence
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Grade DReview2024PubMed metadata verified

MOTS-c modulates skeletal muscle function by directly binding and activating CK2.

Verified PubMed record for MOTS-C: MOTS-c modulates skeletal muscle function by directly binding and activating CK2.

Journal
iScience
Evidence context
Metadata-only, mechanistic, or limited evidence
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