Skip to content
Atlas Research Compounds

Authority cluster

MOTS-C: Mechanism

Mechanistic pathways reported in verified publications, separated from clinical inference.

Mechanistic frame

Investigated as a mitochondrial-derived signaling peptide in cellular stress and metabolic regulation. Mechanistic records below are organized by their actual experimental system. They do not prove a clinical effect.

Publication records

9 verified studies

Search all studies →
Grade DReview2023PubMed metadata verified

MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.

Verified PubMed record for MOTS-C: MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.

Journal
Frontiers in endocrinology
Evidence context
Metadata-only, mechanistic, or limited evidence
Review study record →
Grade DReview2023PubMed metadata verified

MOTS-c Functionally Prevents Metabolic Disorders.

Verified PubMed record for MOTS-C: MOTS-c Functionally Prevents Metabolic Disorders.

Journal
Metabolites
Evidence context
Metadata-only, mechanistic, or limited evidence
Review study record →
Grade DReview2019PubMed metadata verified

MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus.

Verified PubMed record for MOTS-C: MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus.

Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
Evidence context
Metadata-only, mechanistic, or limited evidence
Review study record →
Grade DReview2015PubMed metadata verified

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.

Verified PubMed record for MOTS-C: The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.

Journal
Cell metabolism
Evidence context
Metadata-only, mechanistic, or limited evidence
Review study record →
Grade DReview2024PubMed metadata verified

Mitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination.

Verified PubMed record for MOTS-C: Mitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination.

Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Evidence context
Metadata-only, mechanistic, or limited evidence
Review study record →
Grade BReview2023PubMed metadata verified

MOTS-C: A potential anti-pulmonary fibrosis factor derived from mitochondria.

Verified PubMed record for MOTS-C: MOTS-C: A potential anti-pulmonary fibrosis factor derived from mitochondria.

Journal
Mitochondrion
Evidence context
Human comparative or observational evidence
Review study record →
Grade DReview2022PubMed metadata verified

The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus.

Verified PubMed record for MOTS-C: The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus.

Journal
Pharmacological research
Evidence context
Metadata-only, mechanistic, or limited evidence
Review study record →
Grade DReview2023PubMed metadata verified

Role of MOTS-c in the regulation of bone metabolism.

Verified PubMed record for MOTS-C: Role of MOTS-c in the regulation of bone metabolism.

Journal
Frontiers in physiology
Evidence context
Metadata-only, mechanistic, or limited evidence
Review study record →
Grade DReview2024PubMed metadata verified

MOTS-c modulates skeletal muscle function by directly binding and activating CK2.

Verified PubMed record for MOTS-C: MOTS-c modulates skeletal muscle function by directly binding and activating CK2.

Journal
iScience
Evidence context
Metadata-only, mechanistic, or limited evidence
Review study record →

Related topic hubs

LongevityMetabolismMitochondrial HealthHealthy AgingPeptide Research